Objective The authors explored differentially expressed circRNAs in Acute Ischemic Stroke (AIS) and revealed the role and potential downstream molecular mechanisms of circLOC375190. Methods ...
elegans. Recent studies have revealed that autophagy gene cascades act downstream of IIS, targeting the target of the rapamycin (TOR) signaling pathway as well as mTOR and its downstream effector S6K, ...
Impaired lung function is common in people with a history of tuberculosis. Host-directed therapy added to tuberculosis treatment may reduce lung damage and result in improved lung function. An ...
Consistent with previously published work suggesting that S6K is the principal downstream signal affected by rapamycin, we observed decreased levels of pS6 in rapamycin-treated KC PTEN mice, but not ...
6 NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust and University of Birmingham, Sandwell and West Birmingham NHS Foundation Trust & Institute of ...
PI3K-Akt signalling and ketone body metabolism of tumour cells are associated with CD8+ T cell infiltration in HCC microenvironment. The novel immunophenotypic classification can be recapitulated ...
The study conducted by Fang et al. offers significant and fundamental insights, notably enhancing our understanding of angiogenesis. While some of the claims are supported by convincing experimental ...
Department of Chemistry, Georgia State University, Atlanta, Georgia 30302-3965, United States ...
State Key Laboratory of Natural Medicines, Department of Organic Chemistry, China Pharmaceutical University, Nanjing 210009, China ...
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