[64] Inhibition of PDGF signaling (using anti-PDGFR or RTK) in corneal neovascularization prevents mural cell recruitment to new vessels and causes dropout in established vessels, with combination ...

At later maturation stages, PDGF signaling plays a role in tissue remodeling, cellular differentiation, and key inductive events involved in patterning and morphogenesis. Beyond stimulating ...

Now, researchers have discovered that inhibiting PDGF-CC/PDGFRα signaling can reduce scarring in the brain and improve ...

PDGF and its receptors are implicated in tumorigenesis and angiogenesis, prompting Sebti and colleagues to design a synthetic molecule, called GFB-111, that binds to PDGF. Their new molecule has ...

When investigating signaling pathways and protein activation, one often stimulates the cells to promote the activation, as illustrated by platelet-derived growth factor (PDGF)-BB stimulation of ...

Aberrant activation of the Ras/Raf/MAPK/ERK kinase/extracellular signal-regulated kinase cascade ... able to inhibit VEGF receptors 1, 2 and 3, PDGF receptors α and β, RET, Flt3, c-KIT and ...