If you cannot open Microsoft Office program files, you can start Word, Excel, PowerPoint, Outlook, Publisher, Viso, etc, in Safe Mode in Windows 11/10.

Opening MS Excel in Safe Mode will allow this app to open without any of them. We can then find out if that’s the case. Use the prescribed solution to run Excel in safe mode.

The other option for launching Word, Excel, PowerPoint, or Outlook in Safe Mode is to do it via the Run dialog. Open the search option from the taskbar, type “run” and then choose the Run app ...

A start-up file accessed by Excel during spreadsheet loading can cause Excel to hang or slow down. To find out if this is the problem, open Excel in safe mode.