Purdue Pharma’s Sackler family owners have struck a new agreement to settle mass opioid litigation against them for a total of $6.5 billion, New York Attorney General Letitia James said Thursday.

The Office of the Attorney General came to a $7.4 billion settlement with the Sackler family and their company, Purdue Pharma, over their actions leading up to the opioid crisis, which has killed several hundreds of thousands of people in the last two decades.

Members of the Sackler family who own OxyContin maker Purdue Pharma, and the company itself, agreed to pay up to $7.4 billion to settle lawsuits over the toll of the powerful prescription painkiller.