Which will succeed in that plight, though? That's what we're left to decide as we dive into our NFL Week 16 predictions with picks straight-up and against the spread for the full 16-game slate.

Ready? Let's jump in. All NFL betting courtesy of SportsLine consensus. Which picks can you make with confidence in Week 16? And which Super Bowl contender goes down hard? Visit SportsLine ...

There’s nothing better in sports than a good rivalry, and until the Bills beat the Chiefs in a postseason game, the best one in the NFL remains ... and then again in Week 18 against Cincinnati ...

Ahead of NFL free agency, several big-players could end up as cap casualties as teams release veterans to get their financial ...

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Check out The Arizona Republic's NFL playoff picks and NFL playoff predictions for both ... This team has won seven straight games, including a 36-33 win over the Eagles in Week 16 at home. But, this ...

NFL draft analyst Daniel Jeremiah is almost certain the Arizona Cardinals will use their first pick on an edge rusher and ...

The NFL playoff schedule continues with two games today ... This team has won seven straight games, including a 36-33 win over the Eagles in Week 16 at home. But, this game is being played in ...