SciELO10d
circLOC375190 promotes autophagy through modulation of the mTORC1/TFEB axis in acute ischemic stroke-induced neurological injury
circLOC375190 affects AIS autophagy by regulating the mTORC1/TFEB axis. Therefore, to provide a theoretical foundation for the treatment of AIS, the authors explored the specific mechanism of ...
Frontiers27d
Signaling networks controlling ID and E protein activity in T cell differentiation and function
E and inhibitor of DNA binding (ID) proteins are involved in various cellular developmental processes and effector activities in T cells. Recent findings indicate that E and ID proteins are not only ...
Medscape17d
Cellular signalling
Rad GTPase inhibits the NFκB pathway through interacting with RelA/p65 to impede its DNA binding and target gene transactivation.
Frontiers27d
Advances in reprogramming of energy metabolism in tumor T cells
Cancer is a leading cause of human death worldwide, and the modulation of the metabolic properties of T cells employed in cancer immunotherapy holds great promise for combating cancer. As a crucial ...
BMJ27d
Phosphatidylinositol 3-kinase delta pathway: a novel therapeutic target for Sjögren’s syndrome
6 NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust and University of Birmingham, Sandwell and West Birmingham NHS Foundation Trust & Institute of ...
gut.bmj26d
Targeting mTOR dependency in pancreatic cancer
Consistent with previously published work suggesting that S6K is the principal downstream signal affected by rapamycin, we observed decreased levels of pS6 in rapamycin-treated KC PTEN mice, but not ...
The EMBO Journal26d
Phosphatidylinositol 3‐phosphates—at the interface between cell signalling and membrane traffic
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