If Excel files are not opening on double-click, first try opening the workbook in Safe Mode. If that fails, use the ‘Open and Repair’ feature found under ‘Open’ in the File menu.

If you cannot open Microsoft Office program files, you can start Word, Excel, PowerPoint, Outlook, Publisher, Viso, etc, in Safe Mode in Windows 11/10.

The other option for launching Word, Excel, PowerPoint, or Outlook in Safe Mode is to do it via the Run dialog. Open the search option from the taskbar, type “run” and then choose the Run app ...