GPCR activation induces a conformational change allowing the Gα unit to disengage with the Gβ-Gγ dimer and for the Gα unit to exchange ... 11,12-EET-dependent phosphorylation of ERK, gap junction Cx43 ...

Department of Physiology, State Key Laboratory of Common Mechanism Research for Major Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Basic Medical Sciences and School of Basic Medicine, ...

This was accompanied by an impairment of mitochondrial function with reduced expression of carnitine palmitoyltransferase I and an induction of acyl-coenzyme A oxidase-1 (ACOX1), oxidative stress and ...

This inhibition disrupts downstream pathways such as MAPK/ERK and PI3K/AKT, preventing cancer cell proliferation and inducing apoptosis. The invention also includes delivery mechanisms to enhance the ...

Diacylglycerol kinases (DGKs) are a family of enzymes that regulate the relative levels of diacylglycerol (DAG) and phosphatidic acid (PA) in cells by phosphorylating DAG to produce PA. Both DAG and ...

We exposed isolated proximal colonic mucosa to specific nutrients, which recruited signalling pathways within specific EEC extracellular receptor-regulated kinase (p-ERK) and calmodulin kinase II ...

Immune cells rely on cell-cell communication to specify and fine-tune their responses. They express an extensive network of cell communication modes, including a vast repertoire of cell surface and ...