The authors have generated important resources such as a reference dataset of early primate development by utilizing single-cell transcriptomic technology together with induced pluripotent stem cells ...

Programmable cellular models of embryos, known as embryoids, allow scientists to mimic the first few day of embryonic development.

Adapting the Lancaster protocol for unguided cerebral differentiation (Lancaster et al., 2013), embryoid bodies (EBs) were initially generated. Once successful neuroectoderm induction was achieved by ...

Advancing single-cell research requires precise and reproducible tissue dissociation techniques. Manual methods can introduce variability, compromise cell viability and hinder downstream applications.

Umut A. Gurkan is leading the CASE Biomanufacturing and Microfabrication Laboratory (CASE-BML). Dr. Gurkan’s research is focused on microcirculation, vascular biology, red blood cells, hemoglobin, ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. An evolutionarily conserved micropeptide, ...

Vascular pathologies are prevalent in a broad spectrum of diseases, necessitating a deeper understanding of vascular biology, particularly in overcoming the oxygen and nutrient diffusion limit in ...