Frontiers5d
Targeting Ubiquitin-Proteasome Pathway by Natural Products: Novel Therapeutic Strategy for Treatment of Neurodegenerative Diseases
The ubiquitin proteasome system (UPS), a 76-amino acid complex, is a key regulator of protein catabolism ... CRL4 (Cullin-RING ubiquitin ligase) is an E3 ubiquitin ligase, composed of three subunits ...
Nature5d
Breaking the chains: structure and function of the deubiquitinases
USP44 deubiquitylates CDC20, a co-activator of the E3 ubiquitin ligase anaphase promoting complex or cyclosome (APC/C) that promotes the degradation of many key cell cycle regulators. USP44 ...
Frontiers5d
ASFV pA151R negatively regulates type I IFN production via degrading E3 ligase TRAF6
Mechanically, we demonstrated that E3 ligase TNF receptor–associated factor 6 (TRAF6) participated in the ubiquitination of TBK1 in cGAS-STING signaling pathway. We showed that pA151R interacted with ...
Complex6d
Complex - Top Stories
No, Ye and Bianca Censori Weren't Escorted Out of Grammys 2025 Red Carpet ...