Testing experimental cancer drugs in mouse models with patient-derived tumors could reduce the high failure rate of drugs in early clinical trials, according to a new report.

PDX models are created by implanting patient-derived tumor tissue into immunodeficient mice, preserving essential features such as tumor genetics, microenvironment, and drug response patterns.

New Tool Designed to Provide Biological Relevance in Neuro-Related Drug Research ...

Unlike other pathologies, amyotrophic lateral sclerosis (ALS) cannot be reproduced accurately in animal models, complicating the development of effective drugs. Faced with this challenge, a group ...

Scientists have created a stem cell-derived model of the human embryo in the lab by reprogramming human stem cells. The breakthrough could help research into genetic disorders and in understanding ...

Cambridge scientists have created a stem cell-derived model of the human embryo in the lab by reprogramming human stem cells. The breakthrough could help research into genetic disorders and in ...

The US Food and Drug Administration (FDA) has announced plans to begin replacing animal testing in drug development with “more effective, human-relevant methods”, including AI models and lab ...

Testing experimental cancer drugs in mouse models with patient-derived tumors could reduce the high failure rate of drugs in early clinical trials, according to a report from Dana-Farber Cancer ...