A high-risk form of the disease that is progressive and difficult to treat is often associated with mutations in the ATRX gene, which controls the expression of multiple sections of the genome and ...
Their research indicates that mutations in the ATRX gene, which affect approximately 10 per cent of high-risk neuroblastoma patients, may be responsible for altering the tumour immune microenvironment ...
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Polo-like kinase 1 (PLK1) is a conserved ...
At close: March 14 at 4:00:00 PM EDT ...
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Key hallmarks include abnormal Wnt/β-catenin signaling, disrupted cell cycle (p53-RB, CDK4), chromatin remodeling inhibition (menin, KMT2A-KMT2D, SETD2), DNA repair defects (MMR enzymes, ATM, BRCA1/2, ...
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