Cenicriviroc is a first-in-class inhibitor of the CCR5 and CCR2 receptors that recently completed Phase II evaluation. This drug is promising because of the possibility that CCR2 inhibition may ...

It now aims to run trials of Tobira’s cenicriviroc (a CCR2 and CCR5 inhibitor) and Akarna’s FXR agonist AKN-083, as monotherapies and in combination. Other candidates in the pipeline include ...

To investigate the interaction between macrophages and neutrophils, we performed immunofluorescence staining to label macrophages (F4/80), neutrophils (MPO), and neutrophil signaling receptors (CCR2 ...

BMS-813160 is a dual antagonist of CCR2/CCR5 activation presenting with an excellent human liver microsome stability, oral bioavailability and low clearance in mouse, dog and monkey. It may inhibit ...

For instance, CCR2/CCR5 inhibitors, such as PF-04136309 in pancreatic cancer, could disrupt TAM/Treg recruitment in ESCA, while CXCL8/CXCR2 blockade, trialed in CRC, may reduce MDSC/NET-mediated ...

This important study utilizes humanized mice, in which human immune cells are introduced into immune-deficient mice, to provide convincing evidence that two helper CD4 T-cell subsets, T-follicular ...

In this case–control study, we assessed the relationship of 51 SNPs in 35 genes related to inflammatory response with the risk of ischemic stroke in 1,124 cases and 1,163 controls. In the ...

This study is important, and the findings add substantially to the evidence base regarding CCR5 antagonist drugs for neuroprotection and stroke management. The authors adhered to the expected ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Concurrent analysis of whole-genome DNA ...

Loeys-Dietz syndrome (LDS), caused by mutations in the TGF-β (transforming growth factor-β) signaling cascade, leads to aggressive thoracic aneurysms. While vascular smooth muscle cell (SMC) phenotype ...