CXCL10, CCL4, CCL5, andCCL20, were also reported as possible biomarkers ... targeting chemokine pathways offers therapeutic potential. For instance, CCR2/CCR5 inhibitors, such as PF-04136309 in ...

Glioblastoma constitutes about half of all primary brain tumors and has a median survival time of 10 to 18 months with current standard treatment of maximal primary resection, irradiation, and ...

The chemokine receptors CCR5 and CXCR4 are the two major coreceptors for HIV entry. Numerous efforts have been made to develop a new class of anti-HIV agents that target these coreceptors as an ...

This study is important, and the findings add substantially to the evidence base regarding CCR5 antagonist drugs for neuroprotection and stroke management. The authors adhered to the expected ...

JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong SAR, China Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population ...

Cellular senescence is an important cause of age-related degenerative diseases, including osteoarthritis (OA). Chondrocyte senescence is crucial in OA onset and progression. As a non-invasive, safe, ...

To investigate the interaction between macrophages and neutrophils, we performed immunofluorescence staining to label macrophages (F4/80), neutrophils (MPO), and neutrophil signaling receptors (CCR2 ...

Chronic inflammation of the intestine is a significant risk factor in the development of colorectal cancer. The emergence of colitis and colorectal cancer is a complex, multifactorial process ...