UroToday2d
Stereotactic body radiotherapy for lung oligometastatic prostate cancer: An international retrospective multicenter study.
Management of prostate cancer (PCa) patients with lung oligometastases remains unclear in the absence of published data. The aim of this study was to evaluate the efficacy of Stereotactic Body ...
UroToday2d
TFE3 fusions drive oxidative metabolism and ferroptosis resistance in translocation renal cell carcinoma.
The oncogenic mechanisms by which TFE3 fusion proteins drive translocation renal cell carcinoma (tRCC) are poorly characterized. Here, we integrated loss and gain of function experiments with ...
UroToday2d
Analytical and Real-World Clinical Characterization of S2,3PSA% Test in MRI Fusion Targeted Prostate Biopsy Population.
The α2,3-sialyl N-glycosylated free prostate-specific antigen ratio (S2,3PSA%) was approved in Japan as a prostate cancer (PCa) diagnostic test. We evaluated the analytical characterization and ...
UroToday2d
Feasibility study of using the PREDICT kidney tool for patients with localised renal cell carcinoma.
Localised renal cell carcinoma (RCC) is usually treated surgically, with post-operative imaging-based surveillance to monitor for recurrence. However, surveillance practices vary widely, and patients ...
UroToday2d
LHRH Antagonists Restore Serum Testosterone Faster Than LHRH Agonists in Prostate Cancer Patients After Radiotherapy.
Maintaining a castration level of testosterone (TST) during radiation therapy combined with androgen deprivation therapy (ADT) is an essential strategy in the treatment of prostate cancer; however, ...
UroToday2d
Perioperative cisplatin-based chemotherapy for muscle-invasive bladder cancer: a decision analysis.
While meta-analyses of randomised studies suggest that neoadjuvant (NAC) or adjuvant (ACT) cisplatin-based chemotherapy improve overall survival in patients with muscle-invasive bladder cancer (MIBC), ...
UroToday3d
Cellular Proliferation Imaging with 18F-FMAU PET/CT as Adjunct to mpMRI in Image-Guided Biopsy of Suspected Prostate Cancer - Beyond the Abstract
In view of our prior encouraging preclinical study, in this small-scale pilot human study, we showed that 18F-FMAU PET/CT may complement standard of care mpMRI by potentially detecting additional ...
UroToday3d
Refining Partial Gland Ablation for Localised Prostate Cancer: The FALCON Project - Beyond the Abstract
FALCON: A Consensus to guide the future of focal therapy. FALCON aims to provide clear guidance for partial gland ablation in prostate cancer (PCa). After more than 30 years of research, focal therapy ...
UroToday3d
Enzalutamide in biochemically recurrent prostate cancer: key findings from the EMBARK study.
This podcast features two of the investigators from the international, randomized, phase 3 EMBARK trial (NCT02319837) in conversation. EMBARK evaluated the efficacy and safety of enzalutamide plus ...
UroToday3d
Results of Stereotactic Body Radiation Therapy for Primary Renal Cell Carcinoma in a Large Multicenter Series - Beyond the Abstract
Renal cell carcinoma is frequently discovered at a localized stage in an aging population, which is often frail, comorbid, and unsuitable for surgery. Stereotactic body radiotherapy (SBRT) is gaining ...
UroToday3d
Lower Testosterone level and metastases-free survival in nmCRPC patients treated with novel antiandrogens: A post-hoc analysis of SPARTAN and ARAMIS.
The EAU guidelines and the latest recommendations from the US Prostate Cancer Conference suggest a castration threshold of 20 ng/dl. However, the current NCCN and AUA guidelines still recommend a ...
UroToday3d
BRD9 inhibition as potential treatment option for testicular germ cell tumors.
Testicular germ cell tumors (TGCT) are the predominant tumor in younger males. Usually, 5-year survival rates are quite high, but 15-20% of patients with metastatic non-seminomas are resistant to ...