An international research team has decoded the molecular structure of the medically important serotonin receptor at room temperature for the first time. This study reveals the dynamics of the ...

Antidepressants are used to treat depression as well as other health conditions, such as anxiety, pain, and insomnia. Some of the most common antidepressants are called selective serotonin reuptake ...

Revealing serotonin transporter's molecular structure opens new era of drug treatments for depression and anxiety Date: April 6, 2016 Source: Oregon Health & Science University Summary: ...

In the LeuT–sertraline structure, the drug molecule binds to the extracellular vestibule in the protein in such a way that the two chlorine atoms on the phenyl ring insert into a pocket that is ...

Researchers visualize brain's serotonin pump, provide blueprint for new, more effective SSRIs Revealing serotonin transporter's molecular structure opens new era of drug treatments for depression ...

The first X-ray crystal structure of the mouse serotonin 5-HT3 receptor, a pentameric ligand-gated ion channel, is similar to those of other Cys-loop receptors — though here electron density for ...

A team of researchers from Case Western Reserve University School of Medicine have used Nobel prize-winning microscope technology to see full length serotonin receptors for the first time. The ...

Structures of the serotonin receptor 5-HT 3A R in a variety of functional state in presence of lipids. Light-blue receptors from the left are in serotonin-unbound state with the closed transmembrane ...

Researchers determined the 3-D structure of the serotonin transporter and visualized how two common antidepressants interact with the protein. ... (SSRIs). These work by increasing the amount of ...

A team of researchers from Case Western Reserve University School of Medicine have used Nobel prize-winning microscope technology to see full length serotonin receptors for the first time. The tiny ...