SPRY2 is part of the MAPK/ERK pathway, where it has a prevalent role as inhibitor of the ERK1/2 activation through its interaction with the BRAF kinase. 16 To test the biological function of SPRY2 ...

MAPK signaling via the RAS-RAF-MEK-ERK cascade plays a critical role in cancer growth and proliferation. Alterations in the MAPK/ERK pathway are found in a variety of cancer types, ...

Background: The MAPK\ERK signaling pathway is a major determinant in the control of diverse cellular processes. This pathway is often up-regulated in human tumors and as such has been an attractive ...

Therefore, a combination of ERK inhibition with JSI-1187 and dabrafenib may provide a targeted approach to delay or overcome resistance, as ERK is the most distal kinase of the MAPK signaling pathway.

We hypothesize that profiling of genomic alterations in MAPK/ERK in a large cohort of heavily pretreated progressive mPC patients will provide a robust measure of importance, and reveal recurrent ...

The MAPK pathway is more accurately termed the RAS-RAF-MEK-ERK pathway, and involves the regulation of cell proliferation and survival. It is constitutionally overactive in 30% of cancers.

The low response rate—20%—is comparable to response rates observed in other treatments, such drugs that target MEK enzymes in the MAPK/ERK pathway.

Signaling through the MAPK/ERK pathway is activated through a variety of external stimuli, dependent on the G protein subtype coupled to the GPCR. Detecting ERK1/2 phosphorylation mediated by ...