Aberrant activation of the Ras/Raf/MAPK/ERK kinase/extracellular signal-regulated kinase cascade and the VEGF pathway are commonly observed in breast cancer cells leading to malignant cell ...
and extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) signaling is essential for preserving the intestinal stem cell population during aging. By comparing young ...
The study also demonstrates that glucose metabolism influences extracellular signal-regulated kinase (ERK) signaling pathways ...
Our recent work has shown that Hsp90 is critical for oncogenic RAF kinase-driven ERK activation. The combination of Hsp90 inhibitors with RAF or MEK inhibitors may achieve a better pathway inhibition ...
To determine the TCR signalling capacity of the CD3É› mutant T cells, the authors measured the levels of extracellular signal-regulated kinase (ERK) phosphorylation and CD69 expression.
2020 Oct;61(10):1428-1434. doi: 10.2967/jnumed.120.241984. Epub 2020 Aug 28. PMID: 32859706. Synthesis of the PET Tracer 124I-Trametinib for MAPK/ERK Kinase Distribution and Resistance ...
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