The researchers show that ephrin-B2 regulates the proper spatial activation of VEGFR-2 endocytosis and signaling at the tip cell filopodia. In vitro, endothelial cells from Efnb2-knockout and ...
Resistance to VEGFR inhibitors also develops by induction ... possibly because α-PlGF caused less severe intratumoral hypoxia than α-VEGFR2. Furthermore, α-PlGF did not cause the same adverse ...
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