More than 100 million people in the U.S. will be in the path of an intense March storm starting Friday as the sprawling multi-day system threatens fires, blizzards, tornadoes, and flooding as it tracks eastward across the Great Plains.

The forecast comes days after an expansive storm similarly trekked across the U.S. last week, unloading snow in the northern Plains and bringing tornadoes and wildfires to the South. At least five storm-related deaths in Nebraska and Mississippi were tied to that storm.

AccuWeather has declared an extreme risk for severe thunderstorms this Saturday, warning of potential tornadoes.

Numerous significant tornadoes are expected Saturday afternoon and evening, with the highest risk across several states in the Deep South, forecasters say.

At least 17 people have been killed in a monster storm sweeping across much of the U.S. Ten people were killed in Missouri after a tornado outbreak.