Despite its increasing prevalence, a painful condition called bladder pain syndrome, or interstitial cystitis, remains ...

We have discovered that antidepressant drugs, including typical and fast-acting antidepressants, directly bind to TRKB receptors and allosterically promote BDNF signaling. TRKB signaling in turn ...

The team also uncovered the molecular mechanism behind how SH2B1 helps maintain weight, in part by enhancing BDNF/TrkB signaling, which during development promotes brain growth, and in a mature ...

Experiments indicated that a signaling pathway involving BDNF (called the BDNF-TrkB pathway, which helps regulate learning, memory, and communication between neurons) is inhibited in mice with ...

Experiments indicated that a signaling pathway involving BDNF (called the BDNF-TrkB pathway, which helps regulate learning, memory, and communication between neurons) is inhibited in mice with ...