Silent synapses are dormant neural connections that hold untapped brain potential. Discover how ketamine, exercise, and other ...

Researchers have only begun to understand this process at the molecular level, but a functional screen designed by Daniel Peeper and colleagues has identified the neurotrophic receptor TRKB as an ...

The Trophin lab focuses on the role of neurotrophic factors, particularly Brain-Derived Neurotrophic Factor (BDNF) and its receptor TRKB, in plasticity of the adult brain and in the mechanisms of ...

This study provides a potentially useful investigation into the positive role of BDNF/TrkB signaling in implanted dental pulp stem cells to enhance dentin regeneration in the context of dental caries.

2013;8(2):175-192. BDNF and NGF are neurotrophins that promote neuronal survival and plasticity through binding to their specific high-affinity tyrosine kinase receptors (TrkB and TrkA ...

NGF binds to TrkA; BDNF and neurotrophin 4 bind to TrkB; neurotrophin 3 binds to TrkC. BDNF, NGF, and all the receptors are known as targets for therapy in AD. Also, for PD, BDNF is a therapeutic ...

As biomarker testing and the demand for tumor-agnostic therapies rise, ROZLYTREK can potentially target a specialized yet valuable market segment. While competition from other TRK inhibitors ...

Research has demonstrated that BDNF binding to a protein known as the TrkB receptor triggers a cascade that promotes the insertion of AMPA receptors into the postsynaptic membrane of silent synapses.

The Trophin lab focuses on the role of Brain-Derived Neurotrophic Factor (BDNF) and its receptor TRKB in the plasticity and in the mechanisms of drugs used for the treatment of brain disorders. We ...