Thrombin is a serine protease whose specificity determines the fate of the blood coagulation cascade. The last in a chain of membrane-bound factors and cofactors (), thrombin cleaves plasma ...

small molecules to directly inhibit the two key proteases in the coagulation cascade: thrombin and factor Xa (FXa). The recent approval of dabigatran etexilate for the prevention of venous ...

The physician is thoroughly aware that prothrombinopenia causes retarded thrombin formation (elevated prothrombin time), which can result in hemorrhagic phenomena. Likewise, deficiency of ...