The discovery may explain why cutting edge CAR T-cell therapy has managed to revolutionized treatment for blood cancer but ...

Maybe an adenine gets swapped with a uracil (a substitution mutation that could also occur with any of the base pairs), or perhaps one or more bases get inserted or deleted. If a mutation actually ...

This process, called mutation, is part of what determines changes in the characteristics of populations across multiple generations. Add Content to Group Bookmark ...

Common mutations in spike (S) protein (left), ... Take the D614G amino-acid substitution in the receptor-binding domain (RBD) of the S protein, for example.

Substitution mutations comprised a large percentage, accounting for 95.21% (995) of these mutations. Deletions and insertions were 4.3% (45) and 0.48% (5), respectively.

"On comparing the patient's and his parents' DNA, the team identified a mutation in the patient that resulted in a single amino acid substitution (N237S) in the ACOX1 protein.

EVscape used a method called EVE20 to predict the effects of substitution mutations in viral proteins on its fitness, i.e., sustained ability to replicate within the host and cause infection.

In addition to the commonly observed K103N substitution, significant levels of resistance were also conferred by K103 mutations involving changes to R, Q, S, T, or H, although each of the latter ...

The approval was based on data from the phase 3 MARIPOSA trial (ClinicalTrials.gov Identifier: NCT04487080), which included patients with EGFR mutation (exon 19 deletions or exon 21 L858R ...

The MARIPOSA trial randomly allocated 1074 patients with exon 19 deletion or exon 21 L858R substitution mutation-positive locally advanced or metastatic NSCLC and no prior systemic therapy for ...