To resolve the structural mechanism and the conformation changes in the self-splicing reactions, Prof. ZHANG Kaiming’s team first designed the substrates for the self-splicing reactions.

The well-known essential pre-mRNA splicing factor U2AF heterodimer (U2AF2–U2AF1) has been considered to mediate early splicing reaction in all introns of different lengths.

Pre-mRNA splicing in a subset of human short introns is governed by a distinct mechanism involving a new splicing factor, new research finds. The interrupted non-coding regions in pre-mRNAs ...

Australian researchers have discovered a promising new strategy to suppress the growth of aggressive and hard-to-treat ...

However, the mechanism for forming this structure has not been sufficiently clarified. Joint research between Kumamoto University, Osaka University, ... (splicing reaction).

W hile some details of the mechanisms of splicing remain to be worked out, it’s known that mature, edited mRNAs result from an interplay between multiple factors within and outside the transcript ...

While humans can escape the heat by seeking shade or shedding layers, plants remain rooted in place. So how do they survive ...

During splicing, U4/U6.U5 normally ensures the immediate and correct re-joining of loose ends after a transcript has been cut. Without USP39, or when subunits are mutated, this re-joining is delayed.

The study investigates the detailed mechanisms of alternative splicing in plant secondary metabolism, focusing on its effects on terpenoids, phenolic compounds, and nitrogen-containing metabolites.