Feeding the organic compound spermidine to mice and fruit flies boosted mitochondrial activity in the animals’ brains and, with it, their cognitive ability, according to a paper in Cell Reports ...

Direct administration of spermidine is an alternative strategy for inducing autophagy and extending lifespan. However, the role of spermidine in the regulation of autophagy and aging upon ...

A study by Zhang et al. now identifies aging-related decline of the polyamine spermidine as a crucial bottleneck for oocyte quality. Supplementation with spermidine rejuvenates oocytes in vitro ...