Prince Frederik of Luxembourg asked his father one final powerful question before dying from a rare POLG Mitochondrial disease aged 22.

The beloved royal died on March 1 from POLG Mitochondrial disease — a rare genetic disorder that affects approximately one in 5,000 people. The genetic disorder affects multiple organ systems and the mitochondria,

Prince Frederik, 22, was a founder and the creative director of a foundation that raised awareness of POLG disorder.