In the world of viral research, uncovering a virus’s weaknesses is often a painstaking process that requires years of ...

"The replication process is carried out by large protein ... "What these cryo-EM images showed us is that the G4 structure ...

As previously mentioned, the location at which a DNA strand begins to unwind into two separate single strands is known as the origin of replication.As shown in Figure 1, when the double helix ...

The replication process is both very rapid and incredibly accurate, ... S. J. Intricacies in ATP-dependent clamp loading: variations across replication systems. Structure 9, 999–1004 (2001).

The process, the researchers report in their study, published in Cell, is much more random than previously suspected. The three enzymes—helicase, primase and polymerase—are also not alwys in sync.

DNA replication was identified in the late 1950s, but since then researchers across the globe have come up short trying to understand exactly how this process was regulated. Now they know.

To get there, many other steps of DNA replication still need to be understood, such as how the melted DNA origin is opened up even more fully to produce the Y-shaped DNA replication fork. “The DNA ...

Scientists have determined at atomic resolution the structure of machinery that drives the process. ... How double-stranded DNA separates into single strands to start the replication process.

At some point, RNA must have replicated itself before the evolutionary arrival of DNA and proteins, and now we might know how.

Genome stability depends, to a great extent, on the accuracy of the DNA replication process. ... Study details ringed structure of ORC in DNA replication. Feb 21, 2017.

By uncovering precisely how G4s can block replication, scientists can now use that understanding to inform future studies and develop treatments that involve this critical cellular process. “If these ...