Previous peptoid synthesis methods would yield a mix of left- and right-handed helices. In nature, proteins need to be in a specific conformation to perform their functions—most being left-handed.

Peptoid synthesis capabilities were supported by the Materials Synthesis and Simulation Across Scales Initiative, a Laboratory Directed Research and Development program at PNNL.

We discuss the rational design of peptoid mimics of the well-known R5/silaffin system, compare their nanoscale properties with peptides, and highlight experimental findings showing the efficacy of ...

A liver-targeted peptoid performed better than an LNP in inducing expression levels of an mRNA-encoded, anti-RSV protein in mice Nutcracker Therapeutics ...

The peptoids used in these experiments included three of the linear peptoids previously studied by Barron's team, as well as four new circularized versions with increased antiviral activity.

Researchers from the Department of Energy's Pacific Northwest National Laboratory (PNNL) and the University of Washington (UW) have successfully designed a bio-inspired molecule that can direct ...

In studies published in Nature Communications ("Assembly of short amphiphilic peptoids into nanohelices with controllable supramolecular chirality") and Angewandte Chemie ("Hierarchical Self-Assembly ...