In vitro, purified PDGFR-stimulatory antibodies triggered pathways that resulted in the intracellular generation of reactive oxygen species and upregulation of type I collagen gene expression ...
PDGF and its receptors are implicated in tumorigenesis and angiogenesis, prompting Sebti and colleagues to design a synthetic molecule, called GFB-111, that binds to PDGF. Their new molecule has ...