A rigorous, international study published in the New England Journal of Medicine has demonstrated the presence of IgG autoantibodies that stimulate the fibroblast receptor for platelet-derived ...

and PAE-β cells express human PDGFR-β. Duolink reagents and two primary antibodies, one targeting human PDGFR-β and one targeting human P(Tyr751) PDGFR-β, correctly revealed strong signals ...

Expert Rev Ophthalmol. 2013;8(6):527-537. Protein kinase C-mediated contraction of RPE cells is stopped by an anti-PDGF antibody. Unfortunately, blocking PDGF is ineffective at suppressing PVR in ...

Researchers at Karolinska Institutet have identified a new mechanism that may improve the treatment of ischemic stroke. The study, published in the Journal of Clinical Investigation, shows that the ...

They observed that inactivation of LRP1 in vascular SMCs of mice caused PDGFR overexpression and abnormal activation of PDGFR signaling. This resulted in disruption of the elastic layer, SMC ...

Monoclonal antibodies generally produce fewer side effects ... Clinical testing of specific PDGF inhibitors for ocular disease began with the use of E10030 (fovista, Ophthotec, Princeton, NJ ...