Two chemical inhibitors have been used to probe the function of PI3K: wortmannin, a fungal metabolite that irreversibly inhibits p110 by reacting covalently with the catalytic site 5, and the ...

PI3K signaling pathways. Upon activation by RTK, GPCR, Integrin, and Ras, p110 loses inhibition by p85 and converts PIP2 to PIP3. PIP3 recruits AKT to the cell membrane, where AKT is activated ...