[78] Several potent non-selective tyrosine kinase inhibitors that interrupt both VEGF and PDGF signaling have been approved for cancer therapy: imatinib, sorafenib, pazopanib, sunitinib ...

Researchers at Karolinska Institutet have identified a new mechanism that may improve the treatment of ischemic stroke. The study, published in the Journal of Clinical Investigation, shows that the ...

At later maturation stages, PDGF signaling plays a role in tissue remodeling, cellular differentiation, and key inductive events involved in patterning and morphogenesis. Beyond stimulating ...

PDGF-AA acted as agents of chaos, binding directly to PDGF receptors on the surface of BM-MSC. This subsequently activated the Hippo signaling pathway, which is responsible for cell regeneration, to ...

The chimeric fusion oncogene early B-cell factor 1–platelet-derived growth factor receptor-β (EBF1 ... that this fusion activates tyrosine kinase signaling, the mechanisms of transformation ...

To a large extent, these effects can be rescued by treatment of chlorate-treated embryos with PDGF-BB, suggesting that sulfated proteoglycans are mediating signaling by this peptide factor. A ...

[64] Inhibition of PDGF signaling (using anti-PDGFR or RTK) in corneal neovascularization prevents mural cell recruitment to new vessels and causes dropout in established vessels, with combination ...