They are formed in a woman's body before birth and have to be on standby for decades to possibly be fertilized one day. But as they age, they accumulate more and more DNA damage. Until now, it has ...

While it has been possible to reconstruct the partial structure of an artificial cell nucleus inside a mouse oocyte, ...

Upon examining their results, Surani et al. noted that activated oocytes alone were not viable; similarly, adding the nucleus from an egg to a regular oocyte did not produce a healthy embryo.

"To prevent that from happening, oocytes normally pass through a quality ... with the nuclear envelope—the membrane surrounding the nucleus. However, the mechanisms by which they carry out ...

This resets the clock of the somatic nucleus to its embryonic state by an ... of the blastocyst formed from the manipulated oocyte. In addition, reliance on human oocytes is itself a source ...