Those germ cells that enter meiosis become oocytes, the source of future eggs. Consequently, females are born with a finite number of oocytes arrested in the first meiotic prophase. Within the ...

They are formed in a woman's body before birth and have to be on standby for decades to possibly be fertilized one day. But as they age, they accumulate more and more DNA damage. Until now, it has ...

Meiosis is the generation of germ cells (eggs ... as it prevents aberrant chromosome asynapsis checkpoint activation and unintended oocyte elimination. In general, the kinetochore position and ...

During meiosis, one progenitor cell duplicates its ... As a key step in this process, in an oocyte—the precursor of an egg—every pair of chromosomes inherited from both parents (e.g ...

and stars indicate clusters of oocytes devoid of hybridization signal. Unlike its DNA repair role in somatic cells, homologous recombination has a distinct role in meiosis in ensuring proper ...

In 2009, she became a Group Leader at the MRC Laboratory of Molecular Biology (LMB). At the LMB, her group carried out the first studies of meiosis in live human oocytes and developed strategies for ...

A research team led by Max Planck director Melina Schuh, head of the Department of Meiosis at the MPI for Multidisciplinary ... “We found that DNA repair slows down in aged oocytes,” says Schuh. “As a ...

Current Biology 34, 5131-5148.e6 (2024). < A mouse oocyte extrudes a polar body. This important step in meiosis ensures that the egg cell conta ... Ninadini Sharma Max Planck Institute for ...