In this article, the authors focus on the cellular and synaptic alterations that occur with traumatic brain injury. Could synaptic cell adhesion molecules be potential targets for future therapeutics?

Synaptic adhesion molecules are thought to play an important role in the regulation of synaptic connection specificity. The immunoglobulin-like subfamily of synaptic adhesion molecules, the 21-member ...

Researchers have found that dendritic spine structural plasticity, a key process underlying learning and memory, requires the linkage of cell adhesion molecules and polymerizing actin by shootin1a.

IgSF11 homophilic adhesion proteins promote layer-specific synaptic assembly of the cortical interneuron subtype. Science Advances , 2021; 7 (29): eabf1600 DOI: 10.1126/sciadv.abf1600 Cite This Page : ...

This work provides molecular insights into the etiology of night blindness as mutations in genes that encode α2δ4 protein were identified in night blind ... Kamasawa, David Fitzpatrick, Wei Li, ...

Meanwhile, synaptic adhesion proteins bind with each other physically and chemically and then transmit cellular signals in both directions. However, how signals are transmitted within cells by ...

Synapses are the contact points in the brain via which nerve cells ‘talk’ to each other. Disturbances in this communication lead to diseases of the nervous system, since altered synaptic ...

They discovered that the mutation drastically reduces α 2 δ-2's surface expression and synaptic localization, which in turn disrupts multiple aspects of neuronal connectivity.

“Nlgn3 encodes a synaptic adhesion molecule, and Nlgn3 mutant mice exhibit a range of behavioral alterations, including motor stereotypies, alterations in social novelty preference, social ...

In a study published last month in Brain Behavior and Immunity, Japanese researchers identified autoantibodies that target a 'synaptic adhesion protein', neurexin 1α, in a subset of patients with ...