. For about a century, the argument for focusing on rare Mendelian disorders was as follows: Mendelian phenotypes will reveal genes involved in common multifactorial traits, metabolic pathways ...

It can be said that polygenic inheritance involves complex ... Many of these congenital birth defects are explained by a multifactorial threshold model. This assumes that the gene defects for ...

Nonsyndromic Hirschsprung disease, hitherto assumed to be a multifactorial disease ... Oligogenic inheritance can explain the main aspects of its genetic epidemiology. Two types of Hirschsprung ...