It can be said that polygenic inheritance involves complex ... Many of these congenital birth defects are explained by a multifactorial threshold model. This assumes that the gene defects for ...

. For about a century, the argument for focusing on rare Mendelian disorders was as follows: Mendelian phenotypes will reveal genes involved in common multifactorial traits, metabolic pathways ...

Nonsyndromic Hirschsprung disease, hitherto assumed to be a multifactorial disease ... Oligogenic inheritance can explain the main aspects of its genetic epidemiology. Two types of Hirschsprung ...