These Dp1Tyb mice also needed louder sounds to initiate a response in their brains, suggesting they had hearing loss. Using gene mapping, the team narrowed down that a gene called Dyrk1a, found on ...

A century after Down syndrome was first described ... induced translocations involving these mouse chromosomes, producing mice that are trisomic for regions suspected to play a role in DS.

There has been no definite link to external stimuli resulting in increased seizure activity, though the association of the syndrome in these mice with movement to different rooms within the ...