and AKT3 work in a cascade to stabilize proteins in the cell nucleus that regulate EMT. Although AXL and TBK1 are already ...

During embryogenesis, the EMT program permits cells that were ... for the execution of most of the steps of the invasion–metastasis cascade. This cascade involves localized invasion by primary ...

A new study published in Engineering has identified enolase 2 (ENO2) as a key factor in the lymphatic metastasis of head and neck squamous cell carcinoma (HNSCC). The research reveals how ENO2 and its ...

Researchers from the Chinese Academy of Sciences developed a coordination nanomedicine (ZnDHT NM) designed for cascade-specific ... to-mesenchymal transition (EMT) and revert to CSC-like states.

The cytokine TGF-β released by polarized macrophages interacted with its receptor TGFβR1 on tumor cells, promoting EMT and migration, which may lead to tumor metastasis. Importantly ...