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Safeguarding intestinal stem cells during aging through balanced signaling
Their findings revealed that IFN-γ signaling activation and ERK/MAPK signaling inactivation contribute to age-related changes in the intestinal epithelium. Using mouse models, the researchers ...
Medscape6d
Clinical Overview of Sorafenib in Breast Cancer
Aberrant activation of the Ras/Raf/MAPK/ERK kinase/extracellular signal-regulated kinase cascade and the VEGF pathway are commonly observed in breast cancer cells leading to malignant cell ...
eLife12d
Evaluation of information flows in the RAS-MAPK system using transfer entropy measurements
Assessment of transfer entropy is useful for network analysis of cell signaling network providing information on the network topology and action points of genetic mutations and drug effect, thus will ...
eLife13d
Plectin-mediated cytoskeletal crosstalk as a target for inhibition of hepatocellular carcinoma growth and metastasis
Plectin drives hepatocellular carcinoma progression and metastasis through cytoskeletal reorganization and oncogenic signaling, making it a promising therapeutic target for overcoming therapy ...
mskcc.org2y
The Jan Grimm Lab
2020 Oct;61(10):1428-1434. doi: 10.2967/jnumed.120.241984. Epub 2020 Aug 28. PMID: 32859706. Synthesis of the PET Tracer 124I-Trametinib for MAPK/ERK Kinase Distribution and Resistance ...