Loss-of-function screens are powerful tools for identifying gene contribution in a given biological context. Over the past decade, the RNA interference technology has become a dominant approach in ...

Calculate (an approximation of) the predictive density, and 2. Minimize the expectation of the loss function under that (approximated) predictive density. (Empirical risk minimization, on the other ...

Although this form of compensation for loss of gene function has been widely observed, the underlying molecular mechanisms and roles in preventing or modifying disease severity are not well ...

In a novel study, researchers from the Icahn School of Medicine at Mount Sinai introduced LoGoFunc, an advanced computational tool that predicts pathogenic gain- and loss-of-function variants ...

15 Mar 2008. Amidst the debate around whether pathogenic mutations of presenilin harm cells by a gain of toxic function, or a loss of essential normal function (see ARF related news story), new ...