The main classes of diuretics and their mechanisms are described below. Loop diuretics These are the most effective type of diuretic, leading to the excretion of up to 20% of the filtered salt ...

[23] Electrolyte imbalance, particularly hypokalemia, is the most common adverse effect of loop diuretics. Through this mechanism, diuretics may increase mortality (especially arrhythmic deaths).

As shown in Panel A, loop diuretics circulate bound ... it contributes to diuretic resistance. Thus, the same mechanisms may contribute to both diuretic resistance and diuretic adaptation.

This review focuses on thiazides, the diuretics most often indicated for long-term therapy for hypertension; loop diuretics and ... Through both mechanisms, potassium is secreted into the lumen ...

Physiologic alterations in CHF, such as changes in absorption, distribution, metabolism, and elimination of drugs, can indeed alter loop diuretic pharmacokinetics; however, these effects do not ...

Additionally, researchers calculated the daily furosemide-equivalent dose among patients taking a loop diuretic. Analyses revealed a total of 22,296 patients (13%) were taking a diuretic.