[23] Electrolyte imbalance, particularly hypokalemia, is the most common adverse effect of loop diuretics. Through this mechanism, diuretics may increase mortality (especially arrhythmic deaths).

The main classes of diuretics and their mechanisms are described below. Loop diuretics These are the most effective type of diuretic, leading to the excretion of up to 20% of the filtered salt ...

Physiologic alterations in CHF, such as changes in absorption, distribution, metabolism, and elimination of drugs, can indeed alter loop diuretic pharmacokinetics; however, these effects do not ...