The significance of the structure of talin for integrin activation gained new perspectives in Sampo Kukkurainen's doctoral dissertation, which used molecular dynamics simulations to study the ...

Members of the integrin family of adhesion molecules are non-covalently-associated α/β heterodimers that mediate cell–cell, cell–extracellular matrix and cell–pathogen interactions by ...

WALTHAM, Mass., Aug. 29, 2023 (GLOBE NEWSWIRE) -- Morphic Therapeutic (Nasdaq: MORF), a biopharmaceutical company developing a new generation of oral integrin therapies for the treatment of ...

Beta-1 integrin, a critical component ... Team tracks integrin's role in lung function (2020, February 7) ... Small molecule inhibitors restore normal BRAF structure, ...

In this valuable study, Kumar et al., provide evidence suggesting that the p130Cas drives the formation of condensates that sprout from focal adhesions to cytoplasm and suppress translation. Pending ...

My laboratory is recognized for studies implicating a key role for inflammation in vascular injury and repair (NHLBI MERIT Award). Our studies have centered on the structure, function, and signaling ...

WALTHAM, Mass., May 18, 2022 (GLOBE NEWSWIRE) -- Morphic Therapeutic (Nasdaq: MORF), a biopharmaceutical company developing a new generation of oral integrin therapies for the treatment of serious ...

Combination with checkpoint inhibitor showed efficacy in checkpoint-resistant models of breast cancer and induced a lasting anti-tumor effect WALTHAM, Mass., April 12, 2021 (GLOBE NEWSWIRE ...