The significance of the structure of talin for integrin activation gained new perspectives in Sampo Kukkurainen's doctoral dissertation, which used molecular dynamics simulations to study the ...

Members of the integrin family of adhesion molecules are non-covalently-associated α/β heterodimers that mediate cell–cell, cell–extracellular matrix and cell–pathogen interactions by ...

In this valuable study, Kumar et al., provide evidence suggesting that the p130Cas drives the formation of condensates that sprout from focal adhesions to cytoplasm and suppress translation. Pending ...

My laboratory is recognized for studies implicating a key role for inflammation in vascular injury and repair (NHLBI MERIT Award). Our studies have centered on the structure, function, and signaling ...