iPSC-derived organoids differentiate and self-organize to recapitulate the structural features and cell–cell exchanges of mature tissue, and they are becoming increasingly complex. 1 Ainscough said ...

In a step toward treating mitochondrial diseases, researchers in the Netherlands have successfully edited harmful mutations ...

More information: Post-gastrulation amnioids as a stem cell-derived model of human extra-embryonic development, Cell (2025). DOI: 10.1016/j.cell.2025.04.025.

Scientists with the Fralin Biomedical Research Institute at VTC have created an engineered model of the supportive tissue ...

A researcher holding human embryonic stem cell cultures in 2004. In the new research, scientists use human stem cells to make models similar to human embryos. The models cannot develop into fetuses.

A team of researchers in the United States and United Kingdom say they have created the world’s first synthetic human embryo-like structures from stem cells, bypassing the need for eggs and sperm.

During embryonic stem cell (ESC) development, pluripotent stem cells transition from a naïve state into a primed state before they take their first steps toward a lineage commitment. Jacob Hanna, a ...

Casali’s team continually injected immunodeficient mice with human stem cells, which conditioned the mice to produce large amounts of estradiol. Previous work from Casali showed that the estradiol ...

Scientists have devised a new model for studying disorders like autism spectrum disorder and ADHD. It uses clusters of human brain cells grown inside the brain of a rat.

The model and analysis were published in Nature in a report titled, “ A foundation model of transcription across human cell types.”. The newly developed model addresses a gap in current ...