Thus, as HbF increase, an approximately equivalent decrease of the endogenous mouse hemoglobin occurred. Consistently, we obtained similar total hemoglobin levels for SAD, control and all AγSAD mice.

BEAM-101 is a one-time therapy utilizing autologous CD34+ hematopoietic stem and progenitor cells that have been base-edited to potentially increase the production of fetal hemoglobin (HbF), which ...

The investigational therapy aims to restore normal RBC function through increasing levels of hemoglobin F (HbF) by increasing γ-globin protein levels (Fig. 1). γ-globin is a subunit of fetal ...

Target HBF Levels: Success is defined by a mid-single-digit increase in fetal hemoglobin, aiming for a 25% increase to reduce VOCs. Surrogate Endpoint Discussion: Fulcrum supports fetal hemoglobin ...