The fms-like tyrosine kinase 3 (FLT3) plays an important role in both normal and malignant hematopoiesis. Activating mutations in the FLT3 receptor can be detected in approximately 30% of acute ...
FLT3 (Fms-like tyrosine kinase 3), also known as FLK-2 (fetal liver kinase 2) and STK-1 (stem cell kinase 1), is a cell surface tyrosine kinase, belonging to a family of growth factor receptors ...
with the small-molecule protein kinase inhibitor midostaurin (Rydapt, Novartis) in combination with chemotherapy. Midostaurin, which targets the FLT3 receptor (WT and/or mutant), was approved by ...