Overexpression of fibroblast growth factor receptor 3 (FGFR3) has been shown to drive oncogenesis in a subset of patients with multiple myeloma. However, epithelial cancers — such as bladder ...
These malformations are linked to a mutation in FGFR3, a receptor for the FGF8 signal. In the patterned cortical organoids, ...
Gain-of-function mutations in fibroblast growth factor receptor (FGFR ... The key breakthrough came with the application of FGFR3 antagonists, BGJ398 (infigratinib) and BMN111 (vosoritide ...
Genescience Pharmaceuticals Co. Ltd. has prepared and tested new fibroblast growth factor receptor 2 (FGFR2) and/or FGFR3 inhibitors reported to be useful for the treatment of cancer, ...
Gain-of-function mutations in fibroblast growth factor receptor (FGFR ... (Hch), the researchers examined the impact of FGFR2 and FGFR3 mutations on mandibular bone formation and repair.
11 xenograft mouse model, accompanied with inhibition of phospho-FGFR3, phospho-JAK2, phospho-STAT3 and Cyclin D2 levels. In sum, AZD1480 blocks proliferation, survival, FGFR3 and JAK/STAT3 ...
BALVERSA (erdafitinib) has strong market potential in the FGFR-altered urothelial carcinoma space, particularly as a targeted therapy for patients wi ...
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